Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

The blood–brain barrier (BBB) protects the central nervous system from infections or harmful
substances; its impairment can lead to or exacerbate various diseases of the central nervous …

Inflammation drives pathology in many human diseases for which there are no disease-
modifying drugs. Inflammasomes are signalling platforms that can induce pathological …

Pyroptosis is a cell death process characterized by cell swelling until membrane rupture and
release of intracellular contents. As an effective tumor treatment strategy, inducing tumor cell …

Inflammasome sensors activate cellular signaling machineries to drive inflammation and cell
death processes. Inflammasomes also control the development of certain diseases …

Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune
system to fight tumors and generally results in robust antitumor immunity. Although …

The determination of a protein's structure is often a first step towards the development of a
mechanistic understanding of its function. Considerable advances in computational protein …

Caspase-1 is one of the main mediators of inflammatory caspases and has become a
correspondent with inflammation, cell death, and several inflammatory diseases. In this …

Programmed cell death (PCD) plays a crucial role in maintaining tissue homeostasis, with its
primary forms including apoptosis, pyroptosis, and necroptosis. The caspase family is …