Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities

E Candelario-Jalil, RM Dijkhuizen, T Magnus - Stroke, 2022‏ - ahajournals.org
Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central
nervous system. Structurally comprising the BBB, brain endothelial cells interact with …

Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021‏ - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Inflammatory responses after ischemic stroke

JH DeLong, SN Ohashi, KC O'Connor… - Seminars in …, 2022‏ - Springer
Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021‏ - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter, J Anrather - The Journal of clinical …, 2020‏ - jci.org
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Ischaemic stroke

BCV Campbell, DA De Silva, MR Macleod… - Nature reviews Disease …, 2019‏ - nature.com
Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in develo** countries. Ischaemic stroke caused by arterial …

Global brain inflammation in stroke

K Shi, DC Tian, ZG Li, AF Ducruet, MT Lawton… - The Lancet …, 2019‏ - thelancet.com
Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal
cell death and the release of factors such as damage-associated molecular patterns …

Extracellular vesicle–mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models

L Yang, B Han, Z Zhang, S Wang, Y Bai, Y Zhang… - Circulation, 2020‏ - ahajournals.org
Background: Stroke is a leading cause of adult disability that can severely compromise the
quality of life of patients, yet no effective medication currently exists to accelerate …

Thrombo-inflammation in acute ischaemic stroke—implications for treatment

G Stoll, B Nieswandt - Nature Reviews Neurology, 2019‏ - nature.com
Ischaemic stroke elicits a strong neuroinflammatory response, but the functional relevance
and therapeutic potential of neuroinflammation has only recently become apparent. In acute …

Short-chain fatty acids improve poststroke recovery via immunological mechanisms

R Sadler, JV Cramer, S Heindl, S Kostidis… - Journal of …, 2020‏ - jneurosci.org
Recovery after stroke is a multicellular process encompassing neurons, resident immune
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …