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Survey of the year 2004 commercial optical biosensor literature
RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2005 - Wiley Online Library
The year 2004 represents a milestone for the biosensor research community: in this year,
over 1000 articles were published describing experiments performed using commercially …
over 1000 articles were published describing experiments performed using commercially …
[HTML][HTML] HIV envelope: challenges and opportunities for development of entry inhibitors
M Caffrey - Trends in microbiology, 2011 - cell.com
The HIV envelope proteins glycoprotein 120 (gp120) and glycoprotein 41 (gp41) play crucial
roles in HIV entry, therefore they are of extreme interest in the development of novel …
roles in HIV entry, therefore they are of extreme interest in the development of novel …
[HTML][HTML] Identification of N-phenyl-N′-(2, 2, 6, 6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4
We have identified two N-phenyl-N′-(2, 2, 6, 6-tetramethyl-piperidin-4-yl)-oxalamide
analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors …
analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors …
Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole …
Reactions of hydrazonoyl halides and each of methyl 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3-
triazol-4-yl) ethylidene) hydrazine-1-carbodithioate and 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3 …
triazol-4-yl) ethylidene) hydrazine-1-carbodithioate and 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3 …
[HTML][HTML] Development of protein-and peptide-based HIV entry inhibitors targeting gp120 or gp41
Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and
mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant …
mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant …
Protein-and peptide-based virus inactivators: inactivating viruses before their entry into cells
X Su, Q Wang, Y Wen, S Jiang, L Lu - Frontiers in Microbiology, 2020 - frontiersin.org
Infectious diseases caused by human immunodeficiency virus (HIV) and other highly
pathogenic enveloped viruses, have threatened the global public health. Most antiviral …
pathogenic enveloped viruses, have threatened the global public health. Most antiviral …
[HTML][HTML] Mechanism of multivalent nanoparticle encounter with HIV-1 for potency enhancement of peptide triazole virus inactivation
AR Bastian, A Nangarlia, LD Bailey, A Holmes… - Journal of Biological …, 2015 - Elsevier
Entry of HIV-1 into host cells remains a compelling yet elusive target for develo** agents
to prevent infection. A peptide triazole (PT) class of entry inhibitor has previously been …
to prevent infection. A peptide triazole (PT) class of entry inhibitor has previously been …
Quantitative estimate index for early-stage screening of compounds targeting protein-protein interactions
Drug-likeness quantification is useful for screening drug candidates. Quantitative estimates
of drug-likeness (QED) are commonly used to assess quantitative drug efficacy but are not …
of drug-likeness (QED) are commonly used to assess quantitative drug efficacy but are not …
Discovery of novel anti-HIV agents via Cu (I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry-based approach
P Gao, L Sun, J Zhou, X Li, P Zhan… - Expert Opinion on Drug …, 2016 - Taylor & Francis
Introduction: In recent years, a variety of new synthetic methodologies and concepts have
been proposed in the search for new pharmaceutical lead structures and optimization …
been proposed in the search for new pharmaceutical lead structures and optimization …
Toward rational design of novel anti-cancer drugs based on targeting, solubility, and bioavailability exemplified by 1, 3, 4-thiadiazole derivatives synthesized under …
HRM Rashdan, MM Farag, MS El-Gendey… - Molecules, 2019 - mdpi.com
The 1, 3, 4-thiadiazole derivatives (9a–i) were synthesized under solvent free conditions and
their chemical composition was confirmed using different spectral tools (IR, Mass, and NMR …
their chemical composition was confirmed using different spectral tools (IR, Mass, and NMR …