Immunity to fungal infections

L Romani - Nature Reviews Immunology, 2004 - nature.com
The topic of immunity to fungal infections is of interest to a wide range of disciplines, from
microbiology to immunology. It is of particular interest in terms of therapy of HIV-infected …

NETs: a new strategy for using old weapons

V Papayannopoulos, A Zychlinsky - Trends in immunology, 2009 - cell.com
As key players in the host innate immune response, neutrophils are recruited to sites of
infection and constitute the first line of defense. They employ three strategies to eliminate …

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2

BN Gantner, RM Simmons, SJ Canavera… - The Journal of …, 2003 - rupress.org
Toll-like receptors (TLRs) mediate recognition of a wide range of microbial products
including lipopolysaccharides, lipoproteins, flagellin, and bacterial DNA, and signaling …

Surface hydrophobin prevents immune recognition of airborne fungal spores

V Aimanianda, J Bayry, S Bozza, O Kniemeyer… - Nature, 2009 - nature.com
The air we breathe is filled with thousands of fungal spores (conidia) per cubic metre, which
in certain composting environments can easily exceed 109 per cubic metre. They originate …

Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth

RU Ibarra, JS Edwards, BO Palsson - Nature, 2002 - nature.com
Annotated genome sequences, can be used to reconstruct whole-cell metabolic networks,,,.
These metabolic networks can be modelled and analysed (computed) to study complex …

Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species

C Paulussen, JE Hallsworth… - Microbial …, 2017 - Wiley Online Library
Fungi of the genus Aspergillus are widespread in the environment. Some Aspergillus
species, most commonly Aspergillus fumigatus, may lead to a variety of allergic reactions …

Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

C Garlanda, E Hirsch, S Bozza, A Salustri, M De Acetis… - Nature, 2002 - nature.com
Pentraxins are a superfamily of conserved proteins that are characterized by a cyclic
multimeric structure. The classical short pentraxins, C-reactive protein (CRP) and serum …

What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis

A Abad, JV Fernández-Molina, J Bikandi… - Revista iberoamericana …, 2010 - Elsevier
Aspergillus fumigatus is an opportunistic pathogen that causes 90% of invasive aspergillosis
(IA) due to Aspergillus genus, with a 50–95% mortality rate. It has been postulated that …

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

C Steele, RR Rapaka, A Metz, SM Pop… - PLoS …, 2005 - journals.plos.org
Alveolar macrophages represent a first-line innate host defense mechanism for clearing
inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which …

Innate antifungal immunity: the key role of phagocytes

GD Brown - Annual review of immunology, 2011 - annualreviews.org
Fungal diseases have emerged as significant causes of morbidity and mortality, particularly
in immune-compromised individuals, prompting greater interest in understanding the …