Endocrine disrupting chemicals (EDCs) are compounds that alter the structure and function
of the endocrine system and may be contributing to disorders of the reproductive, metabolic …

Quantitative trait loci (QTLs) are being used to study genetic networks, protein functions, and
systems properties that underlie phenotypic variation and disease risk in humans, model …

Idiosyncratic adverse drug reactions (IADRs) encompass a diverse group of toxicities that
can vary by drug and patient. The complex and unpredictable nature of IADRs combined …

The laboratory mouse has served as the premier animal model system for both basic and
preclinical investigations for over a century. However, laboratory mice capture only a subset …

Gene transcription profiles across tissues are largely defined by the activity of regulatory
elements, most of which correspond to regions of accessible chromatin. Regulatory element …

Most standard QTL map** procedures apply to populations derived from the cross of two
parents. QTL detected from such biparental populations are rarely relevant to breeding …

Abstract The Collaborative Cross (CC) is a mouse genetic reference population whose
range of applications includes quantitative trait loci (QTL) map**. The design of a CC QTL …

Clinical trials of tolvaptan showed it to be a promising candidate for the treatment of
Autosomal Dominant Polycystic Kidney Disease (ADPKD) but also revealed potential for …

The explosive spread of Zika virus (ZIKV) has been associated with major variations in
severe disease and congenital afflictions among infected populations, suggesting an …

Background Influenza A virus is a zoonotic pathogen that poses a major threat to human and
animal health. The severe course of influenza infection is not only influenced by viral …