Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Duchenne muscular dystrophy (DMD) is a devastating disease affecting approximately 1 in
every 3,500 male births worldwide. Multiple mutations in the dystrophin gene have been …

Cardiac arrhythmias are a primary contributor to sudden cardiac death, a major unmet
medical need. Because right ventricular (RV) dysfunction increases the risk for sudden …

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the
intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical …

Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca2+ ATPase
(SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) …

Simple Summary Connexin hemichannels are formed by connexin protein family members,
and connect cytosol and extracellular milium. The function of connexin hemichannels cannot …

Aberrant opening of nonjunctional connexin hemichannels at the plasma membrane is
associated with many diseases, including ischemia and muscular dystrophy. Proper control …

Connexins, in particular connexin 43 (Cx43), function as gap junction channels (GJCs) and
hemichannels (HCs). Only recently, specific tools have been developed to study their …

Dystrophin is a large protein serving as local scaffolding repetitively bridging cytoskeleton
and the outside of striated muscle cell. As such dystrophin is a critical brick primarily in …

Aberrant expression of the cardiac gap junction protein connexin-43 (Cx43) has been
suggested as playing a role in the development of cardiac disease in the mdx mouse model …