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Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review
At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
Indazole derivatives and their therapeutic applications: a patent review (2013-2017)
Introduction: Indazoles are heterocyclic moieties rarely found in nature. They are nitrogen
containing chemical compounds composed of a pyrazole ring condensed with a benzene …
containing chemical compounds composed of a pyrazole ring condensed with a benzene …
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
Small-molecule inhibitors of reactive oxygen species production
Reactive oxygen species (ROS) are involved in physiological cellular processes including
differentiation, proliferation, and apoptosis by acting as signaling molecules or regulators of …
differentiation, proliferation, and apoptosis by acting as signaling molecules or regulators of …
Quinoline–sulfonamides as a multi-targeting neurotherapeutic for cognitive decline: In vitro, in silico studies and ADME evaluation of monoamine oxidases and …
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder with multiple
enzymes involved. In the treatment of AD, multifunctional agents targeting cholinesterase …
enzymes involved. In the treatment of AD, multifunctional agents targeting cholinesterase …
Sensitive and selective ratiometric fluorescence probes for detection of intracellular endogenous monoamine oxidase A
Monoamine oxidase A (MAO-A) is known to widely exist in most cell lines in the body, and its
dysfunction (unusually high or low levels of MAO-A) is thought to be responsible for several …
dysfunction (unusually high or low levels of MAO-A) is thought to be responsible for several …
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease
JS Lan, Y Ding, Y Liu, P Kang, JW Hou… - European journal of …, 2017 - Elsevier
Combining N-benzyl pyridinium moiety and coumarin into in a single molecule, novel
hybrids with ChE and MAO-B inhibitory activities were designed and synthesized. The …
hybrids with ChE and MAO-B inhibitory activities were designed and synthesized. The …
Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease
Combining N-benzylpiperidine moiety of donepezil and coumarin into in a single molecule,
novel hybrids with ChE and MAO-B inhibitory activity were designed and synthesized. The …
novel hybrids with ChE and MAO-B inhibitory activity were designed and synthesized. The …
Pristine 2-chloroquinoline-based-thiosemicarbazones as multitarget agents against alzheimer's disease: In vitro and in silico studies of monoamine oxidase (MAO) …
Neurodegenerative diseases can be treated more effectively with multitarget approaches.
monoamine oxidases (MAOs) acetylcholinesterase (AChE) and butyrylcholinesterase …
monoamine oxidases (MAOs) acetylcholinesterase (AChE) and butyrylcholinesterase …
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors
JW Choi, BK Jang, N Cho, JH Park, SK Yeon… - Bioorganic & Medicinal …, 2015 - Elsevier
We have synthesized three categories of α, β-unsaturated carbonyl derivatives and
evaluated their MAO-A and MAO-B inhibitory activities. Among them, compound 10b …
evaluated their MAO-A and MAO-B inhibitory activities. Among them, compound 10b …