Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Following an arterial occlusion outward remodeling of pre-existent inter-connecting
arterioles occurs by proliferation of vascular smooth muscle and endothelial cells. This is …

Exercise training in patients with systolic heart failure (HF) is an accepted adjunct to an
evidence-based management program. This review describes the pathophysiologic features …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Atherosclerosis is inflammation of the vessel wall of the arterial tree. This inflammation
arises at specific areas that experience disturbed blood flow such as bifurcations and the …

Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow.
In endothelial cells (ECs), they function by transducing local blood flow information into …

Primary cilia are mechanosensors for fluid shear stress, and are involved in a number of
syndromes and congenital anomalies. We identified endothelial cilia in areas of low shear …

With the term 'mechanotransduction', it is intended the ability of cells to sense and respond
to mechanical forces by activating intracellular signal transduction pathways and the relative …

Throughout morphogenesis, cells experience intracellular tensile and contractile forces on
microscopic scales. Cells also experience extracellular forces, such as static forces …

Atrioventricular valve development commences with an EMT event whereby endocardial
cells transform into mesenchyme. The molecular events that induce this phenotypic change …