[HTML][HTML] Lipid membrane mimetics in functional and structural studies of integral membrane proteins

S Majeed, AB Ahmad, U Sehar, ER Georgieva - Membranes, 2021 - mdpi.com
Background: Open Access Editor's Choice Review Lipid Membrane Mimetics in Functional
and Structural Studies of Integral Membrane Proteins by Saman Majeed 1, Akram Bani …

The contribution of modern EPR to structural biology

G Jeschke - Emerging Topics in Life Sciences, 2018 - portlandpress.com
Electron paramagnetic resonance (EPR) spectroscopy combined with site-directed spin
labelling is applicable to biomolecules and their complexes irrespective of system size and …

Conformations of influenza A M2 protein in DOPC/DOPS and E. coli native lipids and proteins

G Sanders, PP Borbat, ER Georgieva - Biophysical Journal, 2024 - cell.com
We compared the conformations of the transmembrane domain (TMD) of influenza A M2
(IM2) protein reconstituted in 1, 2-dioleoyl-sn-glycero-3-phosphocholine/1, 2-dioleoyl-sn …

Nanoscale lipid membrane mimetics in spin-labeling and electron paramagnetic resonance spectroscopy studies of protein structure and function

ER Georgieva - Nanotechnology Reviews, 2017 - degruyter.com
Cellular membranes and associated proteins play critical physiological roles in organisms
from all life kingdoms. In many cases, malfunction of biological membranes triggered by …

Paramagnetic species in catalysis research: a unified approach towards (the role of EPR in) heterogeneous, homogeneous and enzyme catalysis

M Bracci, PC Bruzzese, A Famulari, D Fioco, A Guidetti… - 2020 - books.rsc.org
Paramagnetic (open-shell) systems, including transition metal ions, radical intermediates
and defect centres, are often involved in catalytic transformations. Despite the prevalence of …

[HTML][HTML] Molecular biophysics and inhibition mechanism of influenza virus A M2 viroporin by adamantane-based drugs–Challenges in designing antiviral agents

K Georgiou, D Kolokouris, A Kolocouris - Journal of Structural Biology: X, 2025 - Elsevier
The influenza A matrix 2 (AM2) protein is a prototype viroporin that conducts protons through
an array of water molecules and sidechains of ionizable amino acid residues, with His37 …

[HTML][HTML] Highly versatile small virus-encoded proteins in cellular membranes: A structural perspective on how proteins' inherent conformational plasticity couples with …

AS Delkhosh, E Hadadianpour, MM Islam… - Journal of Structural …, 2025 - Elsevier
We investigated several small viral proteins that reside and function in cellular membranes.
These proteins belong to the viroporin family because they assemble into ion-conducting …

Random mutagenesis analysis of the influenza A M2 proton channel reveals novel resistance mutants

P Santner, JMS Martins, C Kampmeyer… - Biochemistry, 2018 - ACS Publications
The influenza M2 proton channel is a major drug target, but unfortunately, the acquisition of
resistance mutations greatly reduces the functional life span of a drug in influenza treatment …

Using pulsed EPR in the structural analysis of integral membrane proteins

AM Hartley, Y Ma, BJ Lane, B Wang, C Pliotas - 2020 - books.rsc.org
Pulsed EPR methods, such as PELDOR (or DEER) and ESEEM have emerged as powerful
tools for assessing membrane protein conformation, folding, oligomerisation and dynamics …

Applications of nitroxide spin labels to structural biology

CS Klug, MT Lerch, JB Feix - 2021 - books.rsc.org
Nitroxide spin labeling was introduced by McConnell and co-workers in the mid-1960s with
the goals of using electron paramagnetic resonance (EPR) spectroscopy to investigate …