Tissue engineering and regenerative medicine has been providing exciting technologies for
the development of functional substitutes aimed to repair and regenerate damaged tissues …

Strategies for bone tissue regeneration have been continuously evolving for the last 25
years since the introduction of the “tissue engineering” concept. The convergence of the life …

Functionally graded materials (FGMs) are innovative materials whose composition and/or
microstructure gradually vary in space according to a designed law. As a result, also the …

Oxidative stress and inflammation are common pathological mechanisms for the
progression of tissue degeneration. Epigallocatechin-3-gallate (EGCG) features antioxidant …

Background Intervertebral disc degeneration has an annual worldwide socioeconomic
impact masked as low back pain of over 70 billion euros. This disease has a high …

Intervertebral disc (IVD) degeneration is frequently associated with Low back pain (LBP),
which can severely reduce the quality of human life and cause enormous economic loss …

The intervertebral disc (IVD) is an important component of the human spine that maintains
physiological motion and distributes loads. Single-or multi-segment degeneration occurs …

Hydrogel is a suitable scaffold for the nucleus pulposus (NP) regeneration. However, its
unmatched mechanical properties lead to implant failure in late-stage disc degeneration …

Intervertebral disc (IVD) degeneration is one of the main causes of low back pain. Current
surgical treatments are complex and generally do not fully restore spine mobility …

Tissue engineering holds potential in the treatment of intervertebral disc degeneration (IDD).
However, implantation of tissue engineered constructs may cause foreign body reaction and …