In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Background: Although high-risk mutations in identified major susceptibility genes (DNA
mismatch repair genes and MUTYH) account for some familial aggregation of colorectal …

Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …

The present article summarizes recent developments in the characterization of genetic
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …

Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis
and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals …

The current understanding of familial colorectal cancer was limited to descriptions of affected
pedigrees until the early 1990s. A series of landscape‐altering discoveries revealed that …

Nearly 15% of melanomas occur in patients with a family history and a subset of these
patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations …

Early-onset colorectal cancer (EOCRC), defined as that diagnosed before the age of 50,
accounts for 10–12% of all new colorectal cancer (CRC) diagnoses. Epidemiological data …

The distribution of telomere length in humans is broad, but it has finite upper and lower
boundaries. Growing evidence shows that there are disease processes that are caused by …