Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND Folliculogenesis occurs in the highly dynamic environment of the ovary.
Follicle cyclic recruitment, neo-angiogenesis, spatial displacement, follicle atresia and …

STUDY QUESTION How does biochemical stimulation or inhibition of the PI3K/Akt/mTOR
pathway affect the activation and the growth of human primordial follicles in vitro …

Cell-cell contact inhibition and the mechanical environment of cells have both been shown
to regulate YAP nuclear localization to modulate cell proliferation. Changes in cellular …

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …

Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes
menstrual disturbances, infertility, and various health problems. Historically, hormone …

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Purpose Mammalian oogenesis and folliculogenesis share a dynamic connection that is
critical for gamete development. For maintenance of quiescence or follicular activation …

Primary ovarian insufficiency (POI) is defined as a reduction in ovarian function before the
expected age of menopause. POI is known to increase the risk of cardiovascular disorders …

Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators
of ovarian function including the formation of the germ cell precursors, termed primordial …