While scientific advances have led to large-scale production and widespread distribution of
vaccines and antiviral drugs, viruses still remain a major cause of human diseases today …

Highlights•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are
important templates for develo** new antibiotics.•Both peptide discovery and application …

The antimicrobial peptide database (APD, http://aps. unmc. edu/AP/) is an original database
initially online in 2003. The APD2 (2009 version) has been regularly updated and further …

Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …

Peptides with diverse amino acid sequences, structures, and functions are essential players
in biological systems. The construction of well-annotated databases not only facilitates …

The antimicrobial peptide database (APD) has served the antimicrobial peptide field for 18
years. Because it is widely used in research and education, this article documents database …

The prevalence of multidrug-resistant (MDR) pathogens raises public fears of untreatable
infections and represents a huge health risk. There is an urgent need to exploit novel …

Frog skin constitutes a rich source of peptides with a wide range of biological properties.
These include host-defense peptides with cytotoxic activities against bacteria, fungi …

The membrane interactions of the antimicrobial peptide aurein 1.2 were studied using a
range of biophysical techniques to determine the location and the mechanism of action in …