Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

Highlights•First FDA approvals for anti-PD-1 antibodies for patients with metastatic
melanoma.•Promising response from ongoing clinical trials with several anti-PD-1/L1 …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
decline of cognitive function. There is no therapy that can halt or reverse its progression …

The European Myeloma Network (EMN) organized two flow cytometry workshops. The first
aimed to identify specific indications for flow cytometry in patients with monoclonal …

Novel effective immunotherapies are needed for patients with multiple myeloma (MM), since
disease recurrence remains a major obstacle. B-cell maturation antigen (BCMA), a cell …

To identify new markers for minimal residual disease (MRD) detection in acute
lymphoblastic leukemia (ALL), we compared genome-wide gene expression of …

Specific serum antibodies mediating humoral immunity and autoimmunity are provided by
mature plasma cells (PC) residing in the bone marrow (BM), yet their dynamics and …

To identify molecularly defined subgroups in multiple myeloma, gene expression profiling
was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients …

Many proliferative, invasive, and immune tolerance mechanisms that support normal human
pregnancy are also exploited by malignancies to establish a nutrient supply and evade or …

The number and activity of osteoclasts (OCs) are strongly enhanced by myeloma cells,
leading to significant bone lesions in patients with multiple myeloma (MM). Mechanisms …