Calcium homeostasis, transporters, and blockers in health and diseases of the cardiovascular system

G Bkaily, D Jacques - International Journal of Molecular Sciences, 2023 - mdpi.com
Calcium is a highly positively charged ionic species. It regulates all cell types' functions and
is an important second messenger that controls and triggers several mechanisms, including …

Tachycardia and atrial fibrillation-related cardiomyopathies: potential mechanisms and current therapies

JA Keefe, R Garber, MD McCauley, XHT Wehrens - Heart Failure, 2024 - jacc.org
Atrial fibrillation (AF) is associated with an increased risk of new-onset ventricular contractile
dysfunction, termed arrhythmia-induced cardiomyopathy (AIC). Although cardioembolic …

Bionic Potassium Ion Channel in Live Cells Repairs Cardiomyocyte Function

X Shen, Q Lu, T Peng, Y Zhang, W Tan… - Journal of the …, 2024 - ACS Publications
The disturbance of potassium current in cardiac myocytes caused by potassium channel
dysfunction can lead to cardiac electrophysiological disorders, resulting in associated …

Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics

S Fang, M Xu, L Cao, X Liu, M Bezulj, L Tan, Z Yuan… - bioRxiv, 2023 - biorxiv.org
Tracing cellular dynamic changes across conditions, time, and space is crucial for
understanding the molecular mechanisms underlying complex biological systems. However …

Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model

D Kabanov, S Vrana Klimovic, D Beckerová… - Scientific Reports, 2024 - nature.com
The combination of aminophylline and salbutamol is frequently used in clinical practice in
the treatment of obstructive lung diseases. While the side effects (including arrhythmias) of …

Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers

P Asghari, DRL Scriven, S Shahrasebi… - Journal of General …, 2024 - rupress.org
We have previously demonstrated that type II ryanodine receptors (RyR2) tetramers can be
rapidly rearranged in response to a phosphorylation cocktail. The cocktail modified …

Non‑synonymous polymorphisms in the HRC and ADRB1 genes may be associated with all‑cause death in patients with non‑ischemic heart failure

TM Telles, BM May, M Pimentel… - Experimental and …, 2023 - spandidos-publications.com
Sudden cardiac death (SCD) is an unpredictable and common mode of death in patients
with heart failure (HF). Alterations in calcium handling may lead to malignant arrhythmias …

Molecular and cellular neurocardiology in heart disease

BA Habecker, DM Bers, SJ Birren… - The Journal of …, 2024 - Wiley Online Library
This paper updates and builds on a previous White Paper in this journal that some of us
contributed to concerning the molecular and cellular basis of cardiac neurobiology of heart …

USP38 exacerbates pressure overload-induced left ventricular electrical remodeling

Y Pan, Z **ao, H Yang, B Kong, H Meng, W Shuai… - Molecular …, 2024 - Springer
Background Ubiquitin-specific protease 38 (USP38), belonging to the USP family, is
recognized for its role in controlling protein degradation and diverse biological processes …

Unraveling the potential of Epicatechin gallate from crataegus oxyacantha in targeting aberrant cardiac Ca2+ signalling proteins: an in-depth in-silico investigation for …

J Praveen, M Anusuyadevi… - Journal of Biomolecular …, 2024 - Taylor & Francis
The cardiovascular sarcoplasmic reticulum (SR) calcium (Ca2+) ATPase is an imperative
determinant of cardiac functionality. In addition, anomalies in Ca2+ handling protein and …