The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds

DC Crans, JJ Smee, E Gaidamauskas… - Chemical reviews, 2004‏ - ACS Publications
Vanadium is a trace element, which may be beneficial and possibly essential in humans1
but certainly essential for some living organisms. 2r11 Metal ions and thus vanadium ions …

Structural and evolutionary relationships among protein tyrosine phosphatase domains

JN Andersen, OH Mortensen, GH Peters… - … and cellular biology, 2001‏ - journals.asm.org
With the current access to the whole genomes of various organisms and the completion of
the first draft of the human genome, there is a strong need for a structure-function …

[HTML][HTML] Crystal structure of the tyrosine phosphatase SHP-2

P Hof, S Pluskey, S Dhe-Paganon, MJ Eck… - Cell, 1998‏ - cell.com
The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 Å resolution, shows how
its catalytic activity is regulated by its two SH2 domains. In the absence of a tyrosine …

[HTML][HTML] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

JO Lee, H Yang, MM Georgescu, A Di Cristofano… - Cell, 1999‏ - cell.com
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer
predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and …

Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox …

JM Denu, KG Tanner - Biochemistry, 1998‏ - ACS Publications
Protein tyrosine phosphatases (PTPs) catalyze the hydrolysis of phosphotyrosine from
specific signal-transducing proteins. Although regulatory mechanisms for protein kinases …

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

MP Myers, JP Stolarov, C Eng, J Li, SI Wang… - Proceedings of the …, 1997‏ - pnas.org
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor
suppression due to their ability to antagonize the growth promoting protein tyrosine kinases …

A model for the mechanism of human topoisomerase I

L Stewart, MR Redinbo, X Qiu, WGJ Hol, JJ Champoux - Science, 1998‏ - science.org
The three-dimensional structure of a 70-kilodalton amino terminally truncated form of human
topoisomerase I in complex with a 22–base pair duplex oligonucleotide, determined to a …

The structure and mechanism of protein phosphatases: insights into catalysis and regulation

D Barford, AK Das, MP Egloff - Annual review of biophysics and …, 1998‏ - annualreviews.org
▪ Abstract Eukaryotic protein phosphatases are structurally and functionally diverse enzymes
that are represented by three distinct gene families. Two of these, the PPP and PPM families …

The Virulence Plasmid of Yersinia, an Antihost Genome

GR Cornelis, A Boland, AP Boyd… - Microbiology and …, 1998‏ - journals.asm.org
The 70-kb virulence plasmid enables Yersinia spp.(Yersinia pestis, Y. pseudotuberculosis,
and Y. enterocolitica) to survive and multiply in the lymphoid tissues of their host. It encodes …

Development of “substrate-trap**” mutants to identify physiological substrates of protein tyrosine phosphatases

AJ Flint, T Tiganis, D Barford, NK Tonks - Proceedings of the National …, 1997‏ - pnas.org
The identification of substrates of protein tyrosine phosphatases (PTPs) is an essential step
toward a complete understanding of the physiological function of members of this enzyme …