The metabolic syndrome—otherwise called syndrome X, insulin resistance syndrome,
Reaven syndrome, and “the deadly quartet”—is the name given to the aggregate of clinical …

Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of diseases, including
simple steatosis, nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular …

Summary Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find
that central application of IL-6 in mice suppresses feeding and improves glucose tolerance …

Metformin, a well known antidiabetic agent that improves peripheral insulin sensitivity, also
elicits anti-inflammatory actions, but its mechanism is unclear. Here, we investigated the …

Glycolipid metabolic disorder is an important cause for the development of type 2 diabetes
mellitus (T2DM). Clarification of the molecular mechanism of metabolic disorder and …

Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most
commonly prescribed drugs in the world. Besides its hypoglycemic effects, metformin also …

Introduction: AMP-activated protein kinase (AMPK) is the downstream component of a
serine/threonine protein kinase cascade involved in the regulation of metabolism. Many …

Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α
secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase …

Background: Diabetes is an increasingly prevalent global disease caused by the impairment
in insulin production or insulin function. Diabetes in the long term causes both microvascular …

Metabolic syndrome (MetS) is highly associated with a modern lifestyle. The prevalence of
MetS has reached epidemic proportion and is still rising. The main cause of MetS and finally …