Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a
protein is determined by its amino acid sequence. This work laid the foundation for the …

Protein phase separation is implicated in formation of membraneless organelles, signaling
puncta and the nuclear pore. Multivalent interactions of modular binding domains and their …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Alternative inclusion of exons increases the functional diversity of proteins. Among
alternatively spliced exons, tissue-specific exons play a critical role in maintaining tissue …

Many studies about classification and the functional annotation of intrinsically disordered
proteins (IDPs) are based on either the occurrence of long disordered regions or the fraction …

Background Sequencing the genomes of the first few eukaryotes created the impression that
gene number shows no correlation with organism complexity, often referred to as the G …

The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …

Alternatively spliced protein segments tend to be intrinsically disordered and contain linear
interaction motifs and/or post-translational modification sites. An emerging concept is that …

Proteins provide much of the scaffolding for life, as well as undertaking a variety of essential
catalytic reactions. These characteristic functions have led us to presuppose that proteins …