Artificial intelligence (AI) stands at the threshold of revolutionizing clinical oncology, with
considerable potential to improve early cancer detection and risk assessment, and to enable …

Pancreatic ductal adenocarcinoma (PDAC) is a digestive system malignancy characterized
by challenging early detection, limited treatment alternatives, and generally poor prognosis …

The KEAP1–NRF2 system induces the expression of antioxidant genes in response to
various types of oxidative stress. Some cancer cells activate this system, which increases …

Cancer classification and biomarker identification are crucial for guiding personalized
treatment. To make effective use of miRNA associations and expression data, we have …

Immune checkpoint inhibitors (ICIs) are effective in treating recurrent/metastatic head and
neck squamous cell carcinoma (HNSCC), but only 20% of patients achieve durable …

Genetic mutations arising from various internal and external factors drive cells to become
cancerous. Cancerous cells undergo numerous changes, including metabolic …

Objectives Oral squamous cell carcinoma (OSCC) is the most common subtype of head and
neck squamous cell carcinoma (HNSCC). Treatment options for OSCC are currently limited …

In Japan, comprehensive genome profiling (CGP) as a companion diagnostic (CDx) has
been covered by public insurance since June 2019, but the proportion of patients with …

Liquid biopsy (LB) is an essential tool for obtaining tumor‐derived materials with minimum
invasion. Bile has been shown to contain much higher free nucleic acid levels than blood …

Simple Summary This retrospective study aimed to determine the optimal timing of active
discontinuation of long-term responders to immune checkpoint inhibitors in patients with …