The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor
family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism …

Gene regulation is a complex and tightly controlled process that defines cell identity, health
and disease, and response to pharmacologic and environmental signals. Recently …

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to
tailor these alterations in gene expression to the requirements of the inflammatory process …

A wide variety of biological experiments rely on the ability to express an exogenous gene in
a transgenic animal at a defined level and in a spatially and temporally controlled pattern …

NF‐κB is responsible for upregulating gene products that control cell survival. In this study,
we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone …

NF-kappa B is a ubiquitous transcription factor. Nevertheless, its properties seem to be most
extensively exploited in cells of the immune system. Among these properties are NF-kappa …

Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

Apoptotic cell death is important in the development and homeostasis of multicellular
organisms and is a highly controlled means of eliminating dangerous, damaged or …