Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

A large group of small Rab GTPases which mediate secretory and endosomal membrane
transport, as well as autophagosome biogenesis, are essential components of vesicle …

Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation
of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric …

Abstract Background Secretory GTPases like Rab27B control vesicle exocytosis and deliver
critical proinvasive growth regulators into the tumor microenvironment. The expression and …

Rab proteins compose the largest family of small GTPases and control the different steps of
intracellular membrane traffic. More recently, they have been shown to also regulate cell …

Cancer still remains as one of the leading causes of death worldwide. Metastasis and
proliferation are abnormally increased in cancer cells that subsequently, mediate resistance …

The immensity of genes and molecules implicated in gastric carcinogenesis is
overwhelming and the relevant importance of some of these molecules is too often unclear …

Epithelial cell carcinogenesis involves the loss of cell polarity, alteration of polarized protein
presentation, dynamic cell morphology changes, increased proliferation, and increased cell …

Background: Amitriptyline has been replaced in many countries by alternative and more
expensive drugs based on claims of improved tolerability and toxicity and despite slightly …

Growing evidence indicates that Rab GTPases, key regulators of intracellular transport in
eukaryotic cells, play an important role in cancer. We analysed the deregulation at the …