Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Bilirubin is a component of the heme catabolic pathway that is essential for liver function and
has been shown to reduce hepatic fat accumulation. High plasma bilirubin levels are …

The discovery of adipokines has revealed adipose tissue as a central node in the interorgan
crosstalk network, which mediates the regulation of multiple organs and tissues. Adipose …

In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …

Bone marrow (BM) microenvironment represents an important compartment of bone that
regulates bone homeostasis and the balance between bone formation and bone resorption …

Agonists for PPARα are used clinically to reduce triglycerides and improve high-density
lipoprotein (HDL) cholesterol levels in patients with hyperlipidemia. Whether the mechanism …

Mesenchymal stem cells (MSCs) encapsulation by three-dimensionally (3D) printed
matrices were believed to provide a biomimetic microenvironment to drive differentiation into …

The biliverdin reductase (BVR) isozymes BVRA and BVRB are cell surface membrane
receptors with pleiotropic functions. This review compares, for the first time, the structural …

Heme oxygenase (HO) is a critical component of the defense mechanism to a wide variety of
cellular stressors. HO induction affords cellular protection through the breakdown of toxic …

Obesity-mediated metabolic syndrome remains the leading cause of death worldwide.
Among many potential targets for pharmacological intervention, a promising strategy …