Proteins are dynamical entities that undergo a plethora of conformational changes,
accomplishing their biological functions. Molecular dynamics simulation and normal mode …

Co-evolution techniques were originally conceived to assist in protein structure prediction by
inferring pairs of residues that share spatial proximity. However, the functional relationships …

The detection of nucleic acids in biofluids is essential for changing the paradigm of disease
diagnosis. As there are very few nucleic acids present in human biofluids, a high sensitivity …

MutS homologs identify base-pairing errors made in DNA during replication and initiate their
repair. In the presence of adenosine triphosphate, MutS induces DNA bending upon …

The tumor suppressor protein p53, a transcription factor playing a key role in cancer
prevention, interacts with DNA as its primary means of determining cell fate in the event of …

Mutant DNAs are important markers useful for the diagnosis of human disease. Single-
nucleotide polymorphisms (SNPs) represent the most common types of DNA mutations. As …

Pseudomonas aeruginosa, a widely distributed opportunistic pathogen, is an important
threat to human health for causing serious infections worldwide. Due to its antibiotic …

Glutathione peroxidase 4 (GPX4) reduces lipid hydroperoxides in lipid membranes,
effectively inhibiting iron-dependent cell death or ferroptosis. The upregulation of the …

In this perspective article, we present a multidisciplinary approach for characterizing protein
structure networks. We first place our approach in its historical context and describe the …

The rapid increase of '-omics' data warrants the reconsideration of experimental strategies to
investigate general protein function. Studying individual members of a protein family is likely …