According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques.
Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances …

Missing values weaken the power of label-free quantitative proteomic experiments to
uncover true quantitative differences between biological samples or experimental …

As a result of recent improvements in mass spectrometry (MS), there is increased interest in
data-independent acquisition (DIA) strategies in which all peptides are systematically …

Recently, many software tools have been developed to perform quantification in LC‐MS
analyses. However, most of them are specific to either a quantification strategy (eg label …

Understanding how oncogenic mutations rewire regulatory-protein networks is important for
rationalizing the mechanisms of oncogenesis and for individualizing anticancer treatments …

Our ability to model the dynamics of signal transduction networks will depend on accurate
methods to quantify levels of protein phosphorylation on a global scale. Here we describe a …

Comprehensive phosphoproteomic analysis of small populations of cells remains a
daunting task due primarily to the insufficient MS signal intensity from low concentrations of …

Liquid chromatography-mass spectrometry is widely used for comparative replicate sample
analysis in proteomics, lipidomics and metabolomics. Before statistical comparison …

Abstract Significance Analysis of INTeractome (SAINT) is a software package for scoring
protein‐protein interactions based on label‐free quantitative proteomics data (eg, spectral …