The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …

REVIEW A variety of key events in apoptosis focus on mitochondria, including the release of
caspase activators (such as cytochrome c), changes in electron transport, loss of …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

During transduction of an apoptotic (death) signal into the cell, there is an alteration in the
permeability of the membranes of the cell's mitochondria, which causes the translocation of …

This review deals with the permeability transition (PT) of isolated mitochondria, a field
spawned at the very beginning of mitochondrial research by the observation that the …

This review provides a selective history of how studies of mitochondrial cation transport (K+,
Na+, Ca2+) developed in relation to the major themes of research in bioenergetics. It then …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …