Vertebrates sequester iron from invading pathogens, and conversely, pathogens express a
variety of factors to steal iron from the host. Recent work has demonstrated that in addition to …

Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …

The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to
pathogens through a mechanism termed “nutritional immunity.” CP binds Mn2+ and Zn2+ …

Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune
response. The current working model states that CP sequesters manganese and zinc from …

Zn2+ ions are essential in many physiological processes, including enzyme catalysis,
protein structural stabilization, and the regulation of many proteins. The affinities of proteins …

In response to microbial infection, the human host deploys metal-sequestering host-defense
proteins, which reduce nutrient availability and thereby inhibit microbial growth and …

The Receptor for Advanced Glycation Endproducts (RAGE) is a multi-ligand receptor of the
immunoglobulin family. RAGE interacts with structurally different ligands probably through …

Human healthy skin is continuously exposed to bacteria, but is particularly resistant to the
common gut bacterium Escherichia coli. We show here that keratinocytes secrete, as the …

The S100 proteins comprise at least 25 members, forming the largest group of EF-hand
signalling proteins in humans. Although the proteins are expressed in many tissues, each …

The S100 family of EF-hand calcium (Ca 2+)-binding proteins is essential for a wide range of
cellular functions. During infection, certain S100 proteins act as damage-associated …