Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …

Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …

Most variants implicated in common human disease by genome-wide association studies
(GWAS) lie in noncoding sequence intervals. Despite the suggestion that regulatory element …

The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …

Relapses (episodic exacerbations of neurological signs or symptoms) are a defining feature
of relapsing-remitting multiple sclerosis (MS), the most prevalent MS phenotype. While their …

Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent
genome-wide association studies (GWAS) have identified immune-related single-nucleotide …

Brain magnetic resonance imaging is an important tool in the diagnosis and monitoring of
multiple sclerosis patients. However, magnetic resonance imaging alone provides limited …

Multiple sclerosis (MS) is a common complex neurodegenerative disease of the central
nervous system. It develops with autoimmune inflammation and demyelination. Genome …

Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system. By
combining longitudinal MRI-based brain morphometry and brain age estimation using …

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in or on various cell types
and have diverse functions. In immune cells nAChRs regulate proliferation, differentiation …