Water is an essential participant in the stability, structure, dynamics, and function of proteins
and other biomolecules. Thermodynamically, changes in the aqueous environment affect …

Protein function depends on transitions from the ground state to higher energy states.
Deviations from the ground-state structure result from chemical reactivity and conformational …

Sequence-directed variations in the canonical DNA double helix structure that retain Watson–
Crick base-pairing have important roles in DNA recognition, topology and nucleosome …

The properties of water in biological systems have been studied for well over a century by a
wide range of physical techniques, but progress has been slow and erratic. Protein …

The perspective reviews quantitative investigations of chemical exchange phenomena in
proteins and other biological macromolecules using NMR spectroscopy, particularly …

Protein structure is inherently dynamic, with function often predicated on excursions from low
to higher energy conformations. For example, X-ray studies of a cavity mutant of T4 …

Water inside biological ion channels regulates the key properties of these proteins, such as
selectivity, ion conductance, and gating. In this article, we measure the picosecond spectral …

Au cours des dernières années, plusieurs nouvelles méthodes de RMN multidimensionnelle
ont été mises au point afin d'étudier la dynamique moléculaire au cours d'une longue …

The already known X-ray structures of lipases provide little evidence about initial, discrete
structural steps occurring in the first phases of their activation in the presence of lipids …

Although water is often hailed as the lubricant of life, a detailed understanding of its role in
many chemical and biological processes still eludes us. In many natural systems, water is …