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Targeting the mitochondria in chronic respiratory diseases
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …
the source of respiratory ATP. Recently published studies have demonstrated that …
Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells
T Takenaka, S Nakai, M Katayama, M Hirano… - International journal of …, 2019 - Elsevier
Extracellular vesicles (exosomes, EVs) are cell membrane particles (30–200 nm) secreted
by virtually all cells. During intercellular communication in the body, secreted EVs play …
by virtually all cells. During intercellular communication in the body, secreted EVs play …
N-cadherin-triggered myosin II inactivation provides tumor cells with a mechanical cell competition advantage and chemotherapy resistance
Z Dai, S Chen, J Shi, M Rui, Q Xu - Developmental Cell, 2025 - cell.com
The concept that mechanical cell competition may contribute to tumor cell expansion has
been widely discussed. However, whether this process could occur during natural tumor …
been widely discussed. However, whether this process could occur during natural tumor …
[HTML][HTML] Inhibition of alternative cancer cell metabolism of EGFR mutated non-small cell lung cancer serves as a potential therapeutic strategy
CY Huang, LH Hsu, CY Chen, GC Chang, HW Chang… - Cancers, 2020 - mdpi.com
Targeted therapy is an efficient treatment for patients with epidermal growth factor receptor
(EGFR) mutations in non-small cell lung cancer (NSCLC). Therapeutic resistance invariably …
(EGFR) mutations in non-small cell lung cancer (NSCLC). Therapeutic resistance invariably …
Insulin receptor preserves mitochondrial function by binding VDAC1 in insulin insensitive mucosal epithelial cells
R Titone, DM Robertson - The FASEB Journal, 2020 - Wiley Online Library
Unlike many epithelial tissues, the corneal epithelium is insulin insensitive, meaning it does
not require insulin for glucose uptake. In this study, we show that insulin differentially …
not require insulin for glucose uptake. In this study, we show that insulin differentially …
[HTML][HTML] Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis
MJ Kim, D Febbraro, S Farkona, T Gillmore, JE Son… - Molecular …, 2021 - Elsevier
Objective Autophagy is a physiological self-eating process that can promote cell survival or
activate cell death in eukaryotic cells. In skeletal muscle, it is important for maintaining …
activate cell death in eukaryotic cells. In skeletal muscle, it is important for maintaining …
Potent Synergistic Effect on C-Myc–Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor
Y ** effective treatments for colorectal cancers through combinations of small-
molecule approaches and immunotherapies present intriguing possibilities for managing …
molecule approaches and immunotherapies present intriguing possibilities for managing …
[PDF][PDF] Uncovering novel drug therapies and targets for amyotrophic lateral sclerosis (ALS) using artificial intelligence (AI)
MA Myszczynska - 2021 - etheses.whiterose.ac.uk
This thesis presents work conducted as a part of a collaboration between The University of
Sheffield and BenevolentAI, a biotechnology company specialising in applying machine …
Sheffield and BenevolentAI, a biotechnology company specialising in applying machine …
Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer
US20240300921A1 - Indole-substituted quinolines and their combination with Plk1
inhibitors for the treatment of cancer - Google Patents US20240300921A1 - Indole-substituted …
inhibitors for the treatment of cancer - Google Patents US20240300921A1 - Indole-substituted …
機能性ペプチド修飾型エクソソームを用いた細胞内への薬物導入技術
中瀬生彦 - Drug Delivery System, 2020 - jstage.jst.go.jp
抄録 細胞分泌小胞を介した細胞間コミュニケーション, および, 小胞を用いた薬物送達が大きく注目
されている. 細胞分泌小胞は, 形成時にサイトゾルに存在する機能性分子, 例えば microRNA …
されている. 細胞分泌小胞は, 形成時にサイトゾルに存在する機能性分子, 例えば microRNA …