Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies
CA Escudero, K Herlitz, F Troncoso, J Acurio… - Frontiers in …, 2016 - frontiersin.org
Preeclampsia is a syndrome characterized by hypertension during pregnancy, which is a
leading cause of morbidity and mortality in both mother and newborn in develo** …
leading cause of morbidity and mortality in both mother and newborn in develo** …
Modulating Phosphorylation by Proximity-Inducing Modalities for Cancer Therapy
Q Zhang, J Yu, Q You, L Wang - Journal of Medicinal Chemistry, 2024 - ACS Publications
Abnormal phosphorylation of proteins can lead to various diseases, particularly cancer.
Therefore, the development of small molecules for precise regulation of protein …
Therefore, the development of small molecules for precise regulation of protein …
Cadmium reduces growth of male fetuses by impairing development of the placental vasculature and reducing expression of nutrient transporters
In utero exposure to the toxic metal cadmium (Cd) alters fetoplacental growth in rodents and
has been inversely associated with birth weight and infant size in some birth cohorts …
has been inversely associated with birth weight and infant size in some birth cohorts …
Pro-angiogenic role of insulin: from physiology to pathology
CA Escudero, K Herlitz, F Troncoso, K Guevara… - Frontiers in …, 2017 - frontiersin.org
The underlying molecular mechanisms involve in the regulation of the angiogenic process
by insulin are not well understood. In this review article, we aim to describe the role of insulin …
by insulin are not well understood. In this review article, we aim to describe the role of insulin …
Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular …
F Troncoso, J Acurio, K Herlitz, C Aguayo, P Bertoglia… - PloS one, 2017 - journals.plos.org
Placentas from gestational diabetes mellitus (GDM) are often hypervascularized; however,
participation of vascular endothelial growth factor (VEGF) and its receptors in this placental …
participation of vascular endothelial growth factor (VEGF) and its receptors in this placental …
Preeclampsia and increased permeability over the blood–brain barrier: A role of vascular endothelial growth receptor 2
L Bergman, J Acurio, J Leon, E Gatu… - American journal of …, 2021 - academic.oup.com
BACKGROUND Cerebral complications in preeclampsia are leading causes of maternal
mortality worldwide but pathophysiology is largely unknown and a challenge to study. Using …
mortality worldwide but pathophysiology is largely unknown and a challenge to study. Using …
Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome
F Troncoso, H Sandoval, B Ibañez… - …, 2023 - Am Heart Assoc
BACKGROUND: Children from pregnancies affected by preeclampsia have an increased
risk of cognitive and behavioral alterations via unknown pathophysiology. We tested the …
risk of cognitive and behavioral alterations via unknown pathophysiology. We tested the …
Are the cognitive alterations present in children born from preeclamptic pregnancies the result of impaired angiogenesis? Focus on the potential role of the VEGF …
E Lara, J Acurio, J Leon, J Penny… - Frontiers in …, 2018 - frontiersin.org
Evidence from clinical studies has proposed that children born from preeclamptic women
have a higher risk of suffering neurological, psychological, or behavioral alterations …
have a higher risk of suffering neurological, psychological, or behavioral alterations …
Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming
Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the
onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is …
onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is …
Vascular endothelial growth factor receptor 2: Molecular mechanism and therapeutic potential in preeclampsia comorbidity with human immunodeficiency virus and …
This review explored the role of vascular endothelial growth factor receptor-2 (VEGFR-2) in
the synergy of preeclampsia (PE), human immunodeficiency virus (HIV), and severe acute …
the synergy of preeclampsia (PE), human immunodeficiency virus (HIV), and severe acute …