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Machine and deep learning for longitudinal biomedical data: a review of methods and applications
A Cascarano, J Mur-Petit… - Artificial Intelligence …, 2023 - Springer
Exploiting existing longitudinal data cohorts can bring enormous benefits to the medical
field, as many diseases have a complex and multi-factorial time-course, and start to develop …
field, as many diseases have a complex and multi-factorial time-course, and start to develop …
Clinical outcome measures in multiple sclerosis: a review
A proper clinical evaluation of patients with Multiple Sclerosis (MS) is of great importance to
detect MS progression. It provides important data for physicians on their daily practice as …
detect MS progression. It provides important data for physicians on their daily practice as …
Serum GFAP and NfL levels differentiate subsequent progression and disease activity in patients with progressive multiple sclerosis
Background and Objectives Neurodegeneration and astrocytic activation are pathologic
hallmarks of progressive multiple sclerosis (MS) and can be quantified by serum …
hallmarks of progressive multiple sclerosis (MS) and can be quantified by serum …
Evaluation of no evidence of disease activity in a 7-year longitudinal multiple sclerosis cohort
Importance With multiple and increasingly effective therapies for relapsing forms of multiple
sclerosis (MS), disease-free status or no evidence of disease activity (NEDA) has become a …
sclerosis (MS), disease-free status or no evidence of disease activity (NEDA) has become a …
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects …
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects …
Exploration of machine learning techniques in predicting multiple sclerosis disease course
Objective To explore the value of machine learning methods for predicting multiple sclerosis
disease course. Methods 1693 CLIMB study patients were classified as increased EDSS≥ …
disease course. Methods 1693 CLIMB study patients were classified as increased EDSS≥ …
Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis
MP Gorman, BC Healy, M Polgar-Turcsanyi… - Archives of …, 2009 - jamanetwork.com
Objective To investigate whether or not the disparity in disease progression in those with
pediatric-onset compared with adult-onset multiple sclerosis (MS) is due to differences in …
pediatric-onset compared with adult-onset multiple sclerosis (MS) is due to differences in …
Neurofilament light chain serum levels correlate with 10‐year MRI outcomes in multiple sclerosis
Objective To assess the value of annual serum neurofilament light (NfL) measures in
predicting 10‐year clinical and MRI outcomes in multiple sclerosis (MS). Methods We …
predicting 10‐year clinical and MRI outcomes in multiple sclerosis (MS). Methods We …
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?
HL Weiner - Annals of Neurology: Official Journal of the …, 2009 - Wiley Online Library
Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …
A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis
HL Weiner - Journal of neurology, 2008 - Springer
Multiple sclerosis is postulated to be a T cell-mediated autoimmune disease characterised
by a relapsing-remitting stage followed by a secondary progressive phase. The relapsing …
by a relapsing-remitting stage followed by a secondary progressive phase. The relapsing …