Machine and deep learning for longitudinal biomedical data: a review of methods and applications

A Cascarano, J Mur-Petit… - Artificial Intelligence …, 2023 - Springer
Exploiting existing longitudinal data cohorts can bring enormous benefits to the medical
field, as many diseases have a complex and multi-factorial time-course, and start to develop …

Clinical outcome measures in multiple sclerosis: a review

H Inojosa, D Schriefer, T Ziemssen - Autoimmunity reviews, 2020 - Elsevier
A proper clinical evaluation of patients with Multiple Sclerosis (MS) is of great importance to
detect MS progression. It provides important data for physicians on their daily practice as …

Serum GFAP and NfL levels differentiate subsequent progression and disease activity in patients with progressive multiple sclerosis

C Barro, BC Healy, Y Liu, S Saxena, A Paul… - Neurology …, 2022 - neurology.org
Background and Objectives Neurodegeneration and astrocytic activation are pathologic
hallmarks of progressive multiple sclerosis (MS) and can be quantified by serum …

Evaluation of no evidence of disease activity in a 7-year longitudinal multiple sclerosis cohort

DL Rotstein, BC Healy, MT Malik, T Chitnis… - JAMA …, 2015 - jamanetwork.com
Importance With multiple and increasingly effective therapies for relapsing forms of multiple
sclerosis (MS), disease-free status or no evidence of disease activity (NEDA) has become a …

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

PL De Jager, X Jia, J Wang, PIW De Bakker… - Nature …, 2009 - nature.com
We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects …

Exploration of machine learning techniques in predicting multiple sclerosis disease course

Y Zhao, BC Healy, D Rotstein, CRG Guttmann… - PloS one, 2017 - journals.plos.org
Objective To explore the value of machine learning methods for predicting multiple sclerosis
disease course. Methods 1693 CLIMB study patients were classified as increased EDSS≥ …

Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis

MP Gorman, BC Healy, M Polgar-Turcsanyi… - Archives of …, 2009 - jamanetwork.com
Objective To investigate whether or not the disparity in disease progression in those with
pediatric-onset compared with adult-onset multiple sclerosis (MS) is due to differences in …

Neurofilament light chain serum levels correlate with 10‐year MRI outcomes in multiple sclerosis

T Chitnis, C Gonzalez, BC Healy… - Annals of clinical …, 2018 - Wiley Online Library
Objective To assess the value of annual serum neurofilament light (NfL) measures in
predicting 10‐year clinical and MRI outcomes in multiple sclerosis (MS). Methods We …

The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?

HL Weiner - Annals of Neurology: Official Journal of the …, 2009 - Wiley Online Library
Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …

A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis

HL Weiner - Journal of neurology, 2008 - Springer
Multiple sclerosis is postulated to be a T cell-mediated autoimmune disease characterised
by a relapsing-remitting stage followed by a secondary progressive phase. The relapsing …