Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Accurate processing of stalled or damaged DNA replication forks is paramount to genomic
integrity and recent work points to replication fork reversal and restart as a central …

Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding
clamp for replicative DNA polymerases and as an essential component of the eukaryotic …

This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …

Upon genotoxic stress, PCNA ubiquitination allows for replication of damaged DNA by
recruiting lesion-bypass DNA polymerases. However, PCNA is also ubiquitinated during …

Although essential for epigenetic inheritance, the transfer of parental histone (H3-H4) 2
tetramers that contain epigenetic modifications to replicating DNA strands is poorly …

Fifty per cent of the genome is discontinuously replicated on the lagging strand as Okazaki
fragments. Eukaryotic Okazaki fragments remain poorly characterized and, because …

▪ Abstract Chromosomal DNA replicases are multicomponent machines that have evolved
clever strategies to perform their function. Although the structure of DNA is elegant in its …

▪ Abstract One strand of cellular DNA is generated as RNA-initiated discontinuous segments
called Okazaki fragments that later are joined. The RNA terminated region is displaced into …