Julia for biologists
Major computational challenges exist in relation to the collection, curation, processing and
analysis of large genomic and imaging datasets, as well as the simulation of larger and …
analysis of large genomic and imaging datasets, as well as the simulation of larger and …
Optimal use of intravenous tranexamic acid for hemorrhage prevention in pregnant women
Background Every 2 minutes, there is a pregnancy-related death worldwide, with one-third
caused by severe postpartum hemorrhage. Although international trials demonstrated the …
caused by severe postpartum hemorrhage. Although international trials demonstrated the …
Randomized phase III study of enzalutamide compared with enzalutamide plus abiraterone for metastatic castration-resistant prostate cancer (Alliance A031201 trial)
PURPOSE Enzalutamide and abiraterone both target androgen receptor signaling but via
different mechanisms. The mechanism of action of one drug may counteract the resistance …
different mechanisms. The mechanism of action of one drug may counteract the resistance …
Pharmacokinetics of piperacillin and tazobactam in critically Ill patients treated with continuous kidney replacement therapy: A mini‐review and population …
DJ Selig, JP DeLuca, KK Chung… - Journal of Clinical …, 2022 - Wiley Online Library
What is known and objective Timely and appropriate dosing of antibiotics is essential for the
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …
Dynamic PET-facilitated modeling and high-dose rifampin regimens for Staphylococcus aureus orthopedic implant–associated infections
Staphylococcus aureus is a major human pathogen causing serious implant–associated
infections. Combination treatment with rifampin (10 to 15 mg/kg per day), which has dose …
infections. Combination treatment with rifampin (10 to 15 mg/kg per day), which has dose …
[HTML][HTML] Pharmacokinetics of high-titer anti–SARS-CoV-2 human convalescent plasma in high-risk children
BACKGROUND While most children who contract COVID-19 experience mild disease, high-
risk children with underlying conditions may develop severe disease, requiring …
risk children with underlying conditions may develop severe disease, requiring …
Meropenem pharmacokinetics in critically ill patients with or without burn treated with or without continuous veno‐venous haemofiltration
Introduction Severe burn injury involves widespread skin and tissue damage leading to
systemic inflammation, hypermetabolism and multi‐organ failure. The hypermetabolic phase …
systemic inflammation, hypermetabolism and multi‐organ failure. The hypermetabolic phase …
Interspecies brain pbpk modeling platform to predict passive transport through the blood–brain barrier and assess target site disposition
The high failure rate of central nervous system (CNS) drugs is partly associated with an
insufficient understanding of target site exposure. Blood–brain barrier (BBB) permeability …
insufficient understanding of target site exposure. Blood–brain barrier (BBB) permeability …
Filter inference: A scalable nonlinear mixed effects inference approach for snapshot time series data
Variability is an intrinsic property of biological systems and is often at the heart of their
complex behaviour. Examples range from cell-to-cell variability in cell signalling pathways to …
complex behaviour. Examples range from cell-to-cell variability in cell signalling pathways to …
Learning pharmacometric covariate model structures with symbolic regression networks
Y Wahlquist, J Sundell, K Soltesz - Journal of Pharmacokinetics and …, 2024 - Springer
Efficiently finding covariate model structures that minimize the need for random effects to
describe pharmacological data is challenging. The standard approach focuses on …
describe pharmacological data is challenging. The standard approach focuses on …