Natural genetic transformation is the active uptake of free DNA by bacterial cells and the
heritable incorporation of its genetic information. Since the famous discovery of …

Streptococcus pneumoniae is a problematic infectious agent, whose seriousness to human
health has been underscored by the recent rise in the frequency of isolation of multidrug …

Competence for genetic transformation in Streptococcus pneumoniae has been known for
three decades to arise in growing cultures at a critical cell density, in response to a secreted …

Insertion-duplication mutagenesis was used to construct a pneumolysin-negative derivative
of Streptococcus pneumoniae. This was achieved by first transforming the nonencapsulated …

Although the polysaccharide capsule of Streptococcus pneumoniae has been recognized as
a sine qua non of virulence, much recent attention has focused on the role of pneumococcal …

psaA encodes a 37-kDa putative pneumococcal surface adhesin. Although its complete
nucleotide sequence has been determined, its contribution to the pathogenicity of …

Insertion-duplication mutagenesis was used to construct an autolysin-negative derivative of
Streptococcus pneumoniae. This derivative was obtained by first transforming the …

Transformation of genetic material between bacteria was first observed in the 1920s using
Streptococcus pneumoniae as a model organism. Since then, the mechanism of …

The nucleotide sequence of comC, the gene encoding the 17-residue competence-
stimulating peptide (CSP) of Streptococcus pneumoniae (LS Havarstein, G …

Pneumococcal surface protein A (PspA) of Streptococcus pneumoniae has been found to
utilize a novel mechanism for anchoring to the bacterial cell surface. In contrast to that of …