FGF/FGFR signaling in health and disease

Y ** the gut microbiota
G Li, C **e, S Lu, RG Nichols, Y Tian, L Li, D Patel… - Cell metabolism, 2017 - cell.com
While activation of beige thermogenesis is a promising approach for treatment of obesity-
associated diseases, there are currently no known pharmacological means of inducing …

Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases

VT Samuel, GI Shulman - Cell metabolism, 2018 - cell.com
NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Metabolic messengers: FGF21

KH Flippo, MJ Potthoff - Nature metabolism, 2021 - nature.com
As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …