The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …
energy production. Several studies have found a relationship between mitochondrial …
[HTML][HTML] Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders
Here we discuss the role of diverse environmental manipulations affecting cognition with
special regard to psychiatric conditions. We present evidence supporting a direct causal …
special regard to psychiatric conditions. We present evidence supporting a direct causal …
Impaired mitochondrial function in psychiatric disorders
Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent
mental illnesses that affect the lives of millions of individuals. Although these disorders have …
mental illnesses that affect the lives of millions of individuals. Although these disorders have …
Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
HB Clay, S Sillivan, C Konradi - International Journal of Developmental …, 2011 - Elsevier
Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways …
This paper reviews new drug targets in the treatment of depression and new drug
candidates to treat depression. Depression is characterized by aberrations in six intertwined …
candidates to treat depression. Depression is characterized by aberrations in six intertwined …
Towards a unified understanding of lithium action in basic biology and its significance for applied biology
Lithium has literally been everywhere forever, since it is one of the three elements created in
the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from …
the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from …
Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications
Bipolar disorder (BD) is a chronic psychiatric illness characterized by severe and biphasic
changes in mood. Several pathophysiological mechanisms have been hypothesized to …
changes in mood. Several pathophysiological mechanisms have been hypothesized to …
Peripheral biomarkers and illness activity in bipolar disorder
Recent evidence suggests that peripheral markers related to oxidative stress, inflammation
and neurotrophins may be altered during mood episodes in bipolar disorder. These can be …
and neurotrophins may be altered during mood episodes in bipolar disorder. These can be …
Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that
alternate between mania and hypomania or between depression and mixed states, often …
alternate between mania and hypomania or between depression and mixed states, often …
Plasma circulating cell-free mitochondrial DNA in depressive disorders
J Fernström, L Ohlsson, M Asp, E Lavant, A Holck… - PLoS …, 2021 - journals.plos.org
Background Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic
molecule and a novel biomarker of psychiatric disorders. Some previous studies reported …
molecule and a novel biomarker of psychiatric disorders. Some previous studies reported …