Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

The participation of astrocytes in brain computation was hypothesized in 1992, coinciding
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to …

Memory encodes past experiences, thereby enabling future plans. The basolateral
amygdala is a centre of salience networks that underlie emotional experiences and thus has …

Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …

Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological
activity, underlies several critical functions, including learning and memory. However, NREM …

Epigenetic mechanisms bridge genetic and environmental factors that contribute to the
pathogenesis of major depression disorder (MDD). However, the cellular specificity and …

Abstract l-Lactate is increasingly appreciated as a key metabolite and signaling molecule in
mammals. However, investigations of the inter-and intra-cellular dynamics of l-lactate are …

The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …