Targeting the gut microbiota-related metabolites for osteoporosis: the inextricable connection of gut-bone axis

YW Zhang, Y Wu, XF Liu, X Chen, JC Su - Ageing research reviews, 2024 - Elsevier
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass,
destruction of bone microstructure, raised bone fragility, and enhanced risk of fractures. The …

[HTML][HTML] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Are oxidative stress and inflammation mediators of bone loss due to estrogen deficiency? A review of current evidence

NV Mohamad, S Ima-Nirwana… - Endocrine, Metabolic & …, 2020 - ingentaconnect.com
Osteoporosis is one of the major health issues associated with menopause-related estrogen
deficiency. Various reports suggest that the hormonal changes related to menopausal …

Effects of (R)-ketamine on reduced bone mineral density in ovariectomized mice: A role of gut microbiota

X Wan, A Eguchi, Y Fujita, L Ma, X Wang, Y Yang… - …, 2022 - Elsevier
Depression is a high risk for osteoporosis, suggesting an association between depression
and low bone mineral density (BMD). We reported that the novel antidepressant (R) …

The functional roles of methionine and arginine in intestinal and bone health of poultry

G Liu, WK Kim - Animals, 2023 - mdpi.com
Simple Summary Intestinal health and bone health are two major contributors to the well-
being of poultry. Maintaining a balanced and healthy status of the intestines and bones can …

Methionine as a double-edged sword in health and disease: Current perspective and future challenges

U Navik, VG Sheth, A Khurana, SS Jawalekar… - Ageing research …, 2021 - Elsevier
Methionine is one of the essential amino acids and plays a vital role in various cellular
processes. Reports advocate that methionine restriction and supplementation provide …

Meta-analysis reveals compositional and functional microbial changes associated with osteoporosis

OS Akinsuyi, LFW Roesch - Microbiology spectrum, 2023 - Am Soc Microbiol
Over the past decade, the role of the gut microbiota in many disease states has gained a
great deal of attention. Mounting evidence from case-control and observational studies has …

Role of toll-like receptor 4 on osteoblast metabolism and function

A Alonso-Pérez, E Franco-Trepat… - Frontiers in …, 2018 - frontiersin.org
Inflammation is a process whose main function is to fight against invading pathogens or
foreign agents. Nonetheless, it is widely accepted that inflammation takes part in multiple …

Systems biology approach delineates critical pathways associated with disease progression in rheumatoid arthritis

SK Srimadh Bhagavatham, SK Pulukool… - Journal of …, 2023 - Taylor & Francis
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease leading to
inflammation, cartilage cell death, synoviocyte proliferation, and increased and impaired …

The immunoreaction and antioxidant capacity of juvenile blunt snout bream (Megalobrama amblycephala) involves the PI3K/Akt/Nrf2 and NF-κB signal pathways in …

K Ji, H Liang, M Ren, X Ge, H Mi, L Pan, H Yu - Fish & Shellfish Immunology, 2020 - Elsevier
A 75-day rearing trail was designed to evaluate the immunoreaction and antioxidant
capacity of juvenile blunt snout bream in response to dietary methionine levels. Three …