Cytoscape is open-source software for integration, visualization and analysis of biological
networks. It can be extended through Cytoscape plugins, enabling a broad community of …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Residue interaction networks (RINs) are an alternative way of representing protein
structures where nodes are residues and arcs physico–chemical interactions. RINs have …

G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and
trigger GDP release. Given that there are∼ 800 human GPCRs and 16 different Gα genes …

Cytoscape is one of the most popular open‐source software tools for the visual exploration
of biomedical networks composed of protein, gene, and other types of interactions. It offers …

Computational analysis and interactive visualization of biological networks and protein
structures are common tasks for gaining insight into biological processes. This protocol …

Topology is at the very heart of chemistry. This stems from the fact that chemical thought,
since its prescientific alchemic origins, focused on the mutual relations between different …

Traditionally, protein structures have been analysed by the secondary structure architecture
and fold arrangement. An alternative approach that has shown promise is modelling …

NetworkView is an application for the display and analysis of protein· RNA interaction
networks derived from structure and/or dynamics. These networks typically model individual …

Visualizations of biomolecular structures empower us to gain insights into biological
functions, generate testable hypotheses, and communicate biological concepts. Typical …