[HTML][HTML] Advances of microfluidic lung chips for assessing atmospheric pollutants exposure

H Wang, F Yin, Z Li, W Su, D Li - Environment International, 2023 - Elsevier
Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some
chemicals, have posed serious threats to the environment and the human's health. The …

Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model

AL Swart, BJ Laventie, R Sütterlin, T Junne… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa, a leading cause of severe hospital-acquired pneumonia, causes
infections with up to 50% mortality rates in mechanically ventilated patients. Despite some …

Advanced models for respiratory disease and drug studies

J Shrestha, KR Paudel, H Nazari… - Medicinal Research …, 2023 - Wiley Online Library
The global burden of respiratory diseases is enormous, with many millions of people
suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed …

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

S Strickson, KF Houslay, VA Negri… - European …, 2023 - publications.ersnet.org
Background Epithelial damage, repair and remodelling are critical features of chronic airway
diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 …

Modeling crevicular fluid flow and host‐Oral microbiome interactions in a gingival crevice‐on‐Chip

H Makkar, Y Zhou, KS Tan, CT Lim… - Advanced Healthcare …, 2023 - Wiley Online Library
Gingival crevice and gingival crevicular fluid (GCF) flow play a crucial role at the gingiva‐
oral microbiome interface which contributes toward maintaining the balance between …

3D-printed airway model as a platform for SARS-CoV-2 infection and antiviral drug testing

Y Lee, MK Lee, HR Lee, B Kim, M Kim, S Jung - Biomaterials, 2024 - Elsevier
We present a bioprinted three-layered airway model with a physiologically relevant
microstructure for the study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models

L Mahieu, L Van Moll, L De Vooght… - FEMS Microbiology …, 2024 - academic.oup.com
Bacterial pneumonia greatly contributes to the disease burden and mortality of lower
respiratory tract infections among all age groups and risk profiles. Therefore, laboratory …

Dynamic monitoring of a 3D-printed airway tissue model using an organic electrochemical transistor

S Chai, Y Lee, RM Owens, HR Lee, Y Lee, W Kim… - Biomaterials, 2025 - Elsevier
Assessing the transepithelial resistance to ion flow in the presence of an electric field
enables the evaluation of the integrity of the epithelial cell layer. In this study, we introduce …

Real‐Time Monitoring of Cellular Barrier Functionality with Dynamic‐Mode Current‐Driven Organic Electrochemical Transistor

K Lieberth, A Pavlou, D Harig… - Advanced Materials …, 2023 - Wiley Online Library
Cellular barriers control fundamental physiological functions in animals and plants. Accurate
detection of barrier dysfunction requires real‐time monitoring. Organic electrochemical …

Epithelial uptake leads to fungal killing in vivo and is aberrant in COPD-derived epithelial cells

M Bertuzzi, GJ Howell, DD Thomson, R Fortune-Grant… - Iscience, 2024 - cell.com
Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings,
representing a constant, possibly fatal, threat to respiratory health. The small size of Af …