Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every
tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular …

Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T
cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy …

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …

Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

SARS-CoV-2 has been spreading around the world for the past year. Recently, several
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …

Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Transforming growth factor β (TGF-β) has long been identified with its intensive involvement
in early embryonic development and organogenesis, immune supervision, tissue repair, and …

Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …

Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …