Gastric cancer (GC) is one of the most common malignancy and leading cause of cancer-
related deaths worldwide. Due to asymptomatic or only nonspecific early symptoms, GC …

Purinergic signaling is a fundamental mechanism used by all cells to control their internal
activities and interact with the environment. A key component of the purinergic system, the …

This review summarizes important information on the ectoenzyme tissue-nonspecific
alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and …

Background Clinical and experimental studies have shown that the myocardial inflammatory
response during pathological events varies between males and females. However, the …

Transient changes in adenosine and dopamine have been measured in vivo, but no studies
have examined if these transient changes occur simultaneously. In this study, we …

Background Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient
oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a …

Background & Aims Metabolic imbalance and inflammation are common features of chronic
liver diseases. Molecular factors controlling these mechanisms represent potential …

Suicide is a major public health priority, and its molecular mechanisms appear to be related
to imbalanced purine metabolism in the brain. This exploratory study investigates purinergic …

Fast-scan cyclic voltammetry (FSCV) is a rapid technique to measure neuromodulators, and
using FSCV, two modes of rapid adenosine have been discovered. Spontaneous transients …

Ischemic stroke causes damage in the brain, and a slow buildup of adenosine is
neuroprotective during ischemic injury. Spontaneous, transient adenosine signaling, lasting …