While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Various binding modes of tunable metal organic frameworks (MOFs) and functional
DNAzymes (Dzs) synergistically catalyze the emergence of abundant functional …

This manuscript categorizes aptamer selection techniques and provides an updated
compilation of aptamer sequences with high specificity for food contaminants. Furthermore …

Oligonucleotides are advancing as essential materials for the development of new
therapeutics, artificial genes, or in storage of information applications. Hitherto, our capacity …

Nucleic-acid catalysts (ribozymes, DNA-and XNAzymes) cleave target (m) RNAs with high
specificity but have shown limited efficacy in clinical applications. Here we report on the in …

Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize
analytes with extraordinary target selectivity and affinity. Despite their promising properties …

Functional DNAs are valuable molecular tools in chemical biology and analytical chemistry
but suffer from low activities due to their limited chemical functionalities. Here, we present a …

In the last three decades, oligonucleotides have been extensively investigated as probes,
molecular ligands and even catalysts within therapeutic and diagnostic applications. The …

The therapeutic performance of DNAzyme‐involved gene silencing is significantly
constrained by inefficient conditional activation and insufficient cofactor supply. Herein, a …

Threose nucleic acid has been considered a potential evolutionary progenitor of RNA
because of its chemical simplicity, base pairing properties and capacity for higher-order …