Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …

Recombinant glycoprotein therapeutics produced in nonhuman mammalian cell lines and/or
with animal serum are often modified with the nonhuman sialic acid N-glycolylneuraminic …

There are slightly over 165 recombinant pharmaceuticals currently approved for human use.
Another 500 protein candidates are in preclinical and clinical development, about 70% of …

Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide
bound to a sialic acid-containing glycan chain, and locate at the plasma membrane …

Sialic acids are common monosaccharides that are widely expressed as outer terminal units
on all vertebrate cell surfaces, and play fundamental roles in cell–cell and cell …

The demand for production of glycoproteins from mammalian cell culture continues with an
increased number of approvals as biopharmaceuticals for the treatment of unmet medical …

Gangliosides are sialic acid‐containing glycosphingolipids. They occur especially on the
cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in …

The description of “serum sickness” more than a century ago in humans transfused with
animal sera eventually led to identification of a class of human antibodies directed against …