The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration

C Altmann, MHH Schmidt - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes mellitus, which appears in one
third of all diabetic patients and is a prominent cause of vision loss. First discovered as a …

The OCT angular sign of Henle fiber layer (HFL) hyperreflectivity (ASHH) and the pathoanatomy of the HFL in macular disease

P Ramtohul, D Cabral, SV Sadda, KB Freund… - Progress in Retinal and …, 2023 - Elsevier
The Henle fiber layer (HFL) is comprised of bundles of unmyelinated photoreceptor axons
intermingled with outer Müller cell processes. The photoreceptor axons extend from the cell …

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects

A Bringmann, I Iandiev, T Pannicke, A Wurm… - Progress in retinal and …, 2009 - Elsevier
Müller cells are active players in normal retinal function and in virtually all forms of retinal
injury and disease. Reactive Müller cells protect the tissue from further damage and …

Müller glial cells in retinal disease

A Bringmann, P Wiedemann - Ophthalmologica, 2011 - karger.com
Virtually all pathogenic stimuli activate Müller cells. Reactive Müller cells exert protective
and toxic effects on photoreceptors and neurons. They contribute to oxidative stress and …

Current concepts in the pathogenesis of age-related macular degeneration

MA Zarbin - Archives of ophthalmology, 2004 - jamanetwork.com
Objective To review and synthesize information concerning the pathogenesis ofage-related
macular degeneration (AMD). Methods Review of the English-language literature. Results …

Age-related macular degeneration

PTVM De Jong - New England Journal of Medicine, 2006 - Mass Medical Soc
Age-Related Macular Degeneration | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease

DA Antonetti, AJ Barber, SK Bronson, WM Freeman… - Diabetes, 2006 - diabetesjournals.org
Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians.
Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 …

Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease

DY Yu, SJ Cringle - Progress in retinal and eye research, 2001 - Elsevier
Maintenance of an adequate oxygen supply to the retina is critical for retinal function. In
species with vascularised retinas, such as man, oxygen is delivered to the retina via a …

Oxidative damage and age-related macular degeneration

BS Winkler, ME Boulton, JD Gottsch… - Molecular …, 1999 - pmc.ncbi.nlm.nih.gov
This article provides current information on the potential role of oxidation in relation to age-
related macular degeneration (AMD). The emphasis is placed on the generation of oxidants …