The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …

Circular RNAs (circRNAs) are recently discovered as a special novel type of endogenous
noncoding RNAs (ncRNAs), which form a covalently closed continuous loop and are highly …

Annotating the molecular basis of human disease remains an unsolved challenge, as 93%
of disease loci are non-coding and gene-regulatory annotations are highly incomplete …

Background The gut microbiome is associated with the response to immunotherapy for
different cancers. However, the impact of the gut microbiome on hepatobiliary cancers …

Loss of gut microbial diversity,,,,–in industrial populations is associated with chronic
diseases, underscoring the importance of studying our ancestral gut microbiome. However …

Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …

Salivary gland cancers (SGCs) are rare, aggressive cancers without effective treatments
when metastasized. We conducted a phase 2 trial evaluating nivolumab (nivo, anti-PD-1) …

Our understanding of how human embryos develop before gastrulation, including spatial
self-organization and cell type ontogeny, remains limited by available two-dimensional …

Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …

Abstract The NHGRI-EBI GWAS Catalog has provided data from published genome-wide
association studies since 2008. In 2015, the database was redesigned and relocated to …