Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain
Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …
mammalian brain into adulthood. Adult neurogenesis has been best described in the …
[HTML][HTML] Genetics, mechanisms, and therapeutic progress in polyglutamine spinocerebellar ataxias
Autosomal dominant cerebellar ataxias (ADCAs) are a group of neurodegenerative
disorders characterized by degeneration of the cerebellum and its connections. All ADCAs …
disorders characterized by degeneration of the cerebellum and its connections. All ADCAs …
Huntington's disease: from pathology and genetics to potential therapies
S Imarisio, J Carmichael, V Korolchuk… - Biochemical …, 2008 - portlandpress.com
Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …
Motor and cognitive improvements in patients with Huntington's disease after neural transplantation
Background Huntington's disease is a neurodegenerative disease of genetic origin that
mainly affects the striatum. It has severe motor and cognitive consequences and, up to now …
mainly affects the striatum. It has severe motor and cognitive consequences and, up to now …
Replicating Huntington's disease phenotype in experimental animals
E Brouillet, F Conde, MF Beal, P Hantraye - Progress in neurobiology, 1999 - Elsevier
Huntington's disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder
characterized by involuntary choreiform movements, cognitive decline and a progressive …
characterized by involuntary choreiform movements, cognitive decline and a progressive …
Stem cells in clinical practice: applications and warnings
D Lodi, T Iannitti, B Palmieri - Journal of Experimental & Clinical Cancer …, 2011 - Springer
Stem cells are a relevant source of information about cellular differentiation, molecular
processes and tissue homeostasis, but also one of the most putative biological tools to treat …
processes and tissue homeostasis, but also one of the most putative biological tools to treat …
Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases
T Alexi, CV Borlongan, RLM Faull, CE Williams… - Progress in …, 2000 - Elsevier
There are three main mechanisms of neuronal cell death which may act separately or
cooperatively to cause neurodegeneration. This lethal triplet of metabolic compromise …
cooperatively to cause neurodegeneration. This lethal triplet of metabolic compromise …
Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results
JS Fink, JM Schumacher, SL Ellias… - Cell …, 2000 - journals.sagepub.com
The observation that fetal neurons are able to survive and function when transplanted into
the adult brain fostered the development of cellular therapy as a promising approach to …
the adult brain fostered the development of cellular therapy as a promising approach to …
Bilateral human fetal striatal transplantation in Huntington's disease
RA Hauser, S Furtado, CR Cimino, H Delgado… - Neurology, 2002 - AAN Enterprises
Background: Transplanted striatal cells have been demonstrated to survive, grow, establish
afferent and efferent connections, and improve behavioral signs in animal models of …
afferent and efferent connections, and improve behavioral signs in animal models of …
[LIVRE][B] Intervening in the brain: changing psyche and society
R Merkel, G Boer, J Fegert, T Galert, D Hartmann… - 2007 - Springer
The Europäische Akademie is concerned with the study of the consequences of scientific
and technological advance both for the individual and for society at large as well as for the …
and technological advance both for the individual and for society at large as well as for the …