Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity
H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …
structure and functional design that leverages on material engineering to modulate its …
Combinatorial therapy in tumor microenvironment: where do we stand?
The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk
Spatially resolved transcriptomics provides genetic information in space toward elucidation
of the spatial architecture in intact organs and the spatially resolved cell-cell …
of the spatial architecture in intact organs and the spatially resolved cell-cell …
[HTML][HTML] Multiple roles for basement membrane proteins in cancer progression and EMT
Metastasis or the progression of malignancy poses a major challenge in cancer therapy and
is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) …
is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) …
A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer
H Schinke, E Shi, Z Lin, T Quadt, G Kranz, J Zhou… - Molecular Cancer, 2022 - Springer
Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a
therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC) …
therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC) …
To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease
The basement membrane (BM) is a special type of extracellular matrix that lines the basal
side of epithelial and endothelial tissues. Functionally, the BM is important for providing …
side of epithelial and endothelial tissues. Functionally, the BM is important for providing …
The functional role of extracellular matrix proteins in cancer
NV Popova, M Jücker - Cancers, 2022 - mdpi.com
Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …
Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade
Pancreatic ductal adenocarcinoma (PDAC) is correlated with poor outcomes because of
limited therapeutic options. Laminin-5 gamma-2 (LAMC2) plays a critical role in key …
limited therapeutic options. Laminin-5 gamma-2 (LAMC2) plays a critical role in key …
Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation
G Lorusso, CB Wyss, F Kuonen, N Vannini… - Science translational …, 2022 - science.org
Brain metastasis is a complication of increasing incidence in patients with breast cancer at
advanced disease stage. It is a severe condition characterized by a rapid decline in quality …
advanced disease stage. It is a severe condition characterized by a rapid decline in quality …
Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants
The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …