Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

Inflammation is an important component of the tumor microenvironment. IL‐1 is an
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …

Summary The interleukin 1 (IL-1) pathway signals through IL-1 receptor type 1 (IL-1R1) and
emerges as a central mediator for systemic inflammation. Aberrant IL-1 signaling leads to a …

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory
component is present also in the microenvironment of tumors that are not epidemiologically …

TAM and other myeloid-derived tumor infiltrating cells are reviewed as pivotal players in the
tumor microenvironment; implications to anti-cancer therapy are described. The …

Fucoxanthin is a well-known carotenoid of the xanthophyll family, mainly produced by
marine organisms such as the macroalgae of the fucus genus or microalgae such as …

The'seed and soil'hypothesis for metastasis sets forth the concept that a conducive
microenvironment, or niche, is required for disseminating tumour cells to engraft distant …

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