Wilms' tumour 1 (WT1) in development, homeostasis and disease
ND Hastie - Development, 2017 - journals.biologists.com
The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …
At the crossroads of fate—somatic cell lineage specification in the fetal gonad
E Rotgers, A Jørgensen, HHC Yao - Endocrine reviews, 2018 - academic.oup.com
The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …
The −KTS splice variant of WT1 is essential for ovarian determination in mice
EP Gregoire, MC De Cian, R Migale, A Perea-Gomez… - Science, 2023 - science.org
Sex determination in mammals depends on the differentiation of the supporting lineage of
the gonads into Sertoli or pregranulosa cells that govern testis and ovary development …
the gonads into Sertoli or pregranulosa cells that govern testis and ovary development …
Development of adrenal cortex zonation
Y ** murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype
Neuroblastoma is the most common extracranial solid tumor and accounts for∼ 10% of
pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is …
pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is …
[HTML][HTML] Adrenal cortex development and related disorders leading to adrenal insufficiency
The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …
[HTML][HTML] PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal
T Dumontet, I Sahut-Barnola, A Septier, N Montanier… - JCI insight, 2018 - ncbi.nlm.nih.gov
The adrenal cortex undergoes remodeling during fetal and postnatal life. How zona
reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher …
reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher …
The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3
V Vidal, S Sacco, AS Rocha, F da Silva… - Genes & …, 2016 - genesdev.cshlp.org
Adrenal glands are zonated endocrine organs that are essential in controlling body
homeostasis. How zonation is induced and maintained and how renewal of the adrenal …
homeostasis. How zonation is induced and maintained and how renewal of the adrenal …
The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys
Development of the adrenal cortex, a vital endocrine organ, originates in the adrenogonadal
primordium, a common progenitor for both the adrenocortical and gonadal lineages in …
primordium, a common progenitor for both the adrenocortical and gonadal lineages in …
Development and function of the fetal adrenal
The adrenal cortex undergoes multiple structural and functional rearrangements to satisfy
the systemic needs for steroids during fetal life, postnatal development, and adulthood. A …
the systemic needs for steroids during fetal life, postnatal development, and adulthood. A …